The first was the civil war, and federal power consolidated for obvious reasons. Easily half the states demonstrated that they could not be trusted to run their own affairs and protect the rights of the citizens enshrined in the Constitution.
The second was more subtle. The reinterpretation of the Constitution that occurred during the Great Depression granted the federal government the authority to regulate commerce within States under the interstate commerce clause. This authority drives everything from farm subsidies to drug regulation. It is a piece of federal power that people can reasonably argue about the virtue of, but in a modern comment deeply interconnected world it's reasonable to believe that the federal government needs limited central economic planning authority for the country to flourish.