That being said he has gone through a divorce, he did lose a good chunk of his assets pretty quickly. Sure it was just a reallocation of assets, but unless you specifically want all of that money in cash you don't need do actually sell it. Banks for example will give you cash against the value of shares, allowing you access to liquid funds while you're slowly selling the equity.
Anything specific cause you want to spend all of that money on will probably have a limit at which you can spend at, there just isn't enough stuff in the world or people offering services to absorb all that wealth instantly. Trying to cure all the world's diseases will very quickly consume all lab and relevant researcher capacity, which will only grow at the rate people start skill retraining to this new lucrative career.
So I'm not sure it matters? I mean assuming the underlying share value doesn't freefall for some reason.