The mantra I follow is "strong opinions held weakly" (meaning, strive to be as well-informed as I can, but be willing to change my mind to even the polar opposite of my current view in light of new evidence)

IMHO, the key is in realizing that your ego has a tendency to gets tangled with the notion of being right. It's a lot easier to "let go" if you internalize the idea that your worth/identity is not the same thing as your beliefs and that a lot of what you think you "know" is actually not factual knowledge, but merely interpretation or inference of previous experiences.