That's not how science works. We may have various bits of logic that can tweak our initial probability analysis, but we have to do the testing. When we change something fundamental, it must be tested, and things in the past that are
similar, but not
identical, are not sufficient. This is especially true for something that is being injected into the entire general population, which calls for the highest level of scientific certainty before proceeding.
"We think based on biochemistry that mRNA acts like this, and we hope it does that, and we think it probably does the other" doesn't carry much weight here. The probability of any element of that chain of logic being wrong is too high.
I'm not saying that testing wasn't done. I'm saying "eh, it's probably OK, mRNA looks pretty safe" is not a useful contribution to this sort of discussion.