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0 pointshandoflixue4y ago0 comments

> You [...] argue that we should hastily generalize safety results to these sub-populations

I never argued for "hasty" or "generalization."

Simple question: which sub-population are you talking about? Please exclude any sub-population where a statistically significant sample of vaccinated individuals already exists, unless your concern is limited solely to long-term side effects.

If you are concerned about long-term side effects, please cite at least one scientific study explaining why you are concerned about that PARTICULAR sub-group being vulnerable to that PARTICULAR side effect - we wouldn't want to waste time if you can't cite any scientific literature supporting your claim

(P.S. I've only made a single comment about vaccinated -vs- unvaccinated, so you might have me confused with someone else in this thread)

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criticaltinker4y ago

Children and pregnant women are the two sub-populations I mentioned previously.

> Given that COVID-19 disease is far milder in the majority of children than in adults, the risk–benefit of a pediatric SARS-CoV-2 vaccine must be carefully weighed [0]

> The prognostic significance, long-term implications and mechanism of this myocardial injury needs to be studied further, especially as vaccination efforts are rolled out to younger children. [1]

> While the safety, immunogenicity, and efficacy data for the 4 authorized vaccines are reassuring so far, none of these vaccines has been systematically studied in pregnant and breastfeeding people [2]

> it is important to remain transparent about the lack of information, acknowledge concerns, and support those who decide to defer vaccination until more data are available [2]

[0] SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges (Feb 2021) https://www.nature.com/articles/s41390-021-01402-z

[1] COVID-19 Vaccination-Associated Myocarditis in Adolescents (August 2021) https://pediatrics.aappublications.org/content/pediatrics/ea...

[2] SARS-CoV-2 Vaccination During Pregnancy: A Complex Decision (April 2021) https://academic.oup.com/ofid/article/8/5/ofab180/6220034

handoflixueOP4y ago

"Even so, given the reassuring safety and efficacy profiles of the SARS-CoV-2 vaccines that have gained UK/US regulatory authorization to date, the known risks of COVID-19 likely outweigh the unclear risks of SARS-CoV-2 vaccines for pregnant and breastfeeding people."

What are you advocating for? Your own Source Two backs me up here - we have plenty of reason to conclude that Covid is the bigger risk despite the lack of studies. It's right there in the "Conclusion" section.

criticaltinker4y ago

> the known risks of COVID-19 likely outweigh the unclear risks of SARS-CoV-2 vaccines for pregnant and breastfeeding people

Emphasis on "likely" - the authors do not conclude with any certainty, they're speculating based on the available evidence, just like you.

I guess your personal threshold for "plenty of reason to conclude" is lower than mine, and that's okay - to each their own.

But it's very clearly spelled out in the sources I cited: currently there is limited evidence demonstrating the safety and benefit profiles needed to conclude that every child and every pregnant woman should be vaccinated.

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0 pointshandoflixue4y ago0 comments

> You [...] argue that we should hastily generalize safety results to these sub-populations

I never argued for "hasty" or "generalization."

(P.S. I've only made a single comment about vaccinated -vs- unvaccinated, so you might have me confused with someone else in this thread)

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criticaltinker4y ago

Children and pregnant women are the two sub-populations I mentioned previously.

> Given that COVID-19 disease is far milder in the majority of children than in adults, the risk–benefit of a pediatric SARS-CoV-2 vaccine must be carefully weighed [0]

> The prognostic significance, long-term implications and mechanism of this myocardial injury needs to be studied further, especially as vaccination efforts are rolled out to younger children. [1]

> it is important to remain transparent about the lack of information, acknowledge concerns, and support those who decide to defer vaccination until more data are available [2]

[0] SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges (Feb 2021) https://www.nature.com/articles/s41390-021-01402-z

[1] COVID-19 Vaccination-Associated Myocarditis in Adolescents (August 2021) https://pediatrics.aappublications.org/content/pediatrics/ea...

[2] SARS-CoV-2 Vaccination During Pregnancy: A Complex Decision (April 2021) https://academic.oup.com/ofid/article/8/5/ofab180/6220034

handoflixueOP4y ago

criticaltinker4y ago

> the known risks of COVID-19 likely outweigh the unclear risks of SARS-CoV-2 vaccines for pregnant and breastfeeding people

Emphasis on "likely" - the authors do not conclude with any certainty, they're speculating based on the available evidence, just like you.

I guess your personal threshold for "plenty of reason to conclude" is lower than mine, and that's okay - to each their own.

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