>If you blow a tire, run into a deer, or have a transmission failure while you are cruising down the highway at 80mph you have seconds (at most) to react and respond
When they happen all you do it move over and come to a stop. Unless you go Full Redditor(TM) and start adding a bunch of extreme control inputs none of these things are that bad. They don't require much reaction at all even if you are paralyzed by indecision it can still turn out fine since all you have to do is stop.
Blowouts are a non-event, IMO, just a flat tire with an extra audio alert.
Automatic transmissions basically don't fail in unsafe ways. Worst case you'll find some extra neutrals and make an ass out of yourself failing to merge or something. Splitting the case on a manual (like you might do if you go for 4th and somehow find 2nd, or jump a vehicle and don't mash the clutch before hitting the ground) is surprisingly uneventful from a maintaining control perspective.
Deer suck, mostly because they tend to break a bunch of expensive cosmetic bits.
Having a hood fly up on you is worse than any of the above events because you can't see. Brake failure kinda sucks too, especially with an automatic trans.