We've definitively established that Clovis populations and all modern Native Americans are genetically related to Beringian populations out of Eurasia. It's reasonable to suspect pre-clovis populations probably came from much the same area, especially given that suggested pre-clovis lithics so closely resemble clovis traditions.

Additionally, the farthest east that we've found evidence of Australasian populations is the Solomon islands, some 7,000+ mi from South America. There's no evidence of habitation on the intervening islands until Austronesian peoples show up much later. As for Africa, we simply have no evidence for it whatsoever.