I somewhat disagree there. IMO you can structure a large application just as well in python as in Java, but it requires more architecture guidance as your degree of freedom is higher. Regarding testing, mypy and later python versions have been a big help there, I don't think it's much of a difference anymore and I'd take it over Node.js for that reason because the core language IMO is more consistent and strict and requires way way less outside dependencies. In fact the standard lib for me is the main reason to choose python today.

So for me it's really performance being the main thing to think about with python. If one anticipates tighter latency or throughput requirements I'd go for something else.