No, not really. KiCAD is more than adequate for DC to GHz range circuitry. Add to that being able to develop custom tools in Python and we are at a point where there's almost no comparison --in favor of KiCAD.
For context, we were doing GHz-speed boards with PCAD back in the dark ages (20 years ago? Can't remember). As someone else mentioned, you work with your board house for controlled impedance manufacturing. Not that big of a deal. Also, you have to understand the subject or it won't go well, no matter what magic and pixie dust the EDA tool might offer. If the designer does not understand transmission lines, software isn't going to save you.
The same is true for power distribution systems. Just 'cause chips are connected to the various voltages on the board it does not mean anything is going to work. PDS design is a subject in and of itself. You can't just throw a bunch of 0.1 µF capacitors at the problem and expect things to work. Much as is the case with transmission lines, when it comes to power distribution for high speed designs, you have to know what you are doing.
We are very seriously considering migrating away from Altium Designer to KiCAD. I spent a good portion of the last couple of weeks taking a look at this in detail.
I am sick and tired of paying thousands of dollars per year to maintain our licenses only to see them pile-on the bugs. Altium has been focusing so much on trying to find a buyer for the company that they have actually done damage to the product and the user base.
For example, nobody I know has any interest in anything involving the cloud when it comes to EDA. Nobody. It is interesting to note that, if you work in an ITAR environment, today, given software realities, KiCAD is far more secure than Altium. I cannot, with a straight face, approach our clients and tell them that Altium Designer isn't reaching outside our network without air-gapping the system. With KiCAD, I can issue such a statement with absolute certainty.
Here's another one: Nobody who knows what they are doing would ever use schematic symbols and PCB footprints from a library. I don't care where they came from. This means libraries have nearly zero value (or negative value) for serious design work. You have to make all of your own symbols and PCB footprints in-house and qualify them for your designs.
Here's an interesting KiCAD advantage: I can actually ship the entire EDA tool with the design. Clients can archive all of it, software and design. That is powerful.
If we make the transition (very likely) we will our annual Altium maintenance fees to the KiCAD organization. For me this isn't about getting free software at all. I prefer to pay for software because it generally means it will be well supported. However, that changes rapidly once it become obvious that the company isn't using the money to actually work on what matters most. By supporting KiCAD financially I would help ensure it keeps moving in the right direction.
Oh, yeah, and code. We can definitely help with plugins and maybe even some main application development or bug-stomping. It would be fun.