I'm going to guess at a number and say you're probably looking at $10-20MM all in.
As far as hiring good designers, you really need the relevant technical background to screen them. Assuming you need a team, I would suggest starting with someone in a director position at a large company with experience in your area of interest. They would be able to more concretely define the project and determine human resource requirements/allocation.
If your ASIC is just large but not complex (meaning lots of repeated structures), and you can get away with just a few strong designers, I would suggest hiring a consultant to help you define the project and screen candidates. EE profs at your local university might be a good start.
Feel free to shoot me an email (in my profile) if you want to describe your project in more depth and I'd be happy to offer what advice I can.