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0 pointsekianjo4y ago0 comments

Mice models have a very bad track record when it comes to humans. Too much junk publications out there to push papers and get credits.

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Nasrudith4y ago

I thought the main point of mouse models was mostly to be a "first pass filter" for substances before moving onto other animals usually, sometimes humans if the straits are desperate enough. Cancer drugs in particular have little concern for long term side effects in their approval pipeline because the alternative may be having no long term.

ekianjoOP4y ago

First pass filters mean nothing when it comes to humans. 95% of all "stuff that works on mice" fails miserably on humans. We should treat such announcements with extreme skepticism.

hungryforcodes4y ago

You have to start somewhere though.

jonplackett4y ago

I would guess things like how nerves and bones work is more similar across species than, say, how drugs might work on the brain, where a mouse brain is a hell of a lot different to human. Is that a reasonable assumption?

Kaibeezy4y ago

I was wondering the same thing. Pluses and minuses...

Rodents represent readily available models that can be used for a deeper understanding of basic biological mechanisms and for proof of concept for preclinical research hypotheses. However, attempts at direct clinical translation to humans have proven problematic or even impossible to date, principally due to issues of scaling and complexity.

https://clinmedjournals.org/articles/ijscrt/international-jo...

AnthonBerg4y ago

If there is a difference, we’ll learn what the difference is, and if there’s another one after that the same, and so on.

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Chris20484y ago

Yes, but publication of hopeful articles should be near the end, not the start.

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