Yes, I've seen issues that affected the entire region. In my specific case, I happened to have an ElastiCache cluster in the affected AZ that became unreachable (my fault for single AZ). But even now, I'm unable to create any new ElastiCache clusters in different AZs (which I wanted to use for manual failover). And there were a lot of errors on the AWS console during the outage.

"almost unusable" is maybe exaggerating, but there were definitely issues affecting more than just the single AZ.