This is something that amazes me. Any time a true High Risk Variant appears, it is clear as day in the system. This was the case with Lambda, Mu (which we predicted to have a limited propensity to proliferate), and now with Omicron. However, there are lineages, which are prospectively dangerous, that we detect. As the classification is relative, there is no fixed threshold beyond which we would call for alert. In the evaluation, we have been looking at 20 sequences per week, as this was roughly the testing capacity of our partners. Going for ONE sequence a week makes us detect some variants a bit later, but still. The sequences and lineages we predicted to be of interest were predominantly spreading afterwards. Some were just a blip on the radar, though. We aimed at sensitivity and not missing ominous signs, rather than specificity. NB: Each week there are thousands (now 12k+) new sequence variants. Out of them we consider 20. And detect most of the variants as early on as on the first day.