Let's take drugs for instance. I'm pro legalization.
The bulk of the harm created by drugs isn't from the drugs, it's from the cartels, gangs, the mafia - and from the police imprisoning users. Allowing the cartels to transact directly with customers doesn't stop that. It allows the narcos to kidnap, murder, rape and fund their empires - so some Russian kid can smoke a joint.
It's actually a way to make the joint smoking kid more likely to be imprisoned because they paid for their drugs not with an envelope of cash nobody will ever be able to trace - but with an immutable, plaintext, public ledger. Entries on the blockchain are prosecution futures for the little guy. As the technology to de-anonymize them automatically becomes more and more mature, it looks less like a great way to pay for drugs and more like a list of people unaware they're awaiting indictment.
It does nothing to reduce the level of imprisonment of users. It makes the harms associated with drugs significantly worse on both ends. The only way to mitigate the harms is to push for legalization.
However, keep in mind that ad hominem attacks are against site rules.
[edit] So you're clear, no, you did not read this reply correctly. I do not believe in accelerationism. Accelerationism is not progressive. Have a good night!