Normally I'd say M0+ is the king and offers good debug facilities over the M0 despite the slightly larger die size.
However, @rurban is probably correct purely because Ambiq is building their portfolio around the M4 (and M33), and they seem to be working hardest in pursuing and patenting IoT layouts/technologies that reduce energy usage.
I love AVR for teaching/learning, but the fact that you can* get a more powerful, larger memory Cortex-M at a much lower cost than, say, an Atmega... I don't know why anyone would choose AVR for a new design outside of niche uses.
(* - pre-2020)