For Illustrator, use CC 2019 to get hi-def display support in the GUI. I don’t use Illustrator much though, so I can’t vouch for how well it works.
Pixelmator on macOS is a good Photoshop replacement.
I got nothing for Lightroom or heavier uses of AE. Or Excel.
Source: portrait photographer for 20+ years that would ditch Adobe in a heartbeat if it were possible.