Glutamate excitotoxicity is at the core of tinnitus, and this is why diet also effects the strength and appearance of my tinnitus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458046/
https://www.sciencedirect.com/science/article/abs/pii/S03785...
Basically, my understanding is that the human body is, for basic evolutionary reasons, really efficient at dealing with glutamate.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940242/figure/...
Therefore this study shows effectiveness that is theoretically higher than regular benzos. I don't think that regular benzos or tofisopam block the AMPA receptors, although their increase in inhibitory GABA has a similar effect. It would make sense to combine benzos with an NMDA antagonist such as e.g memantine in order to reduce excitotoxicity (or weaker ones like magnesium l-threonate)
I advise you to try tofisopam (grandaxin) especially since it is a safe and extensively studied drug. Tofisopam is for sale in the U.S, OTC in practice e.g on rupharma, cosmicnootropics, possibly indiamart, etc You should not take it in combination with klonopin nor any other drug without advice from an expert (spoiler almost no-one is qualified) as interactions are possible. E.g it is a CYP inhibitor like grappefruit juice. note that the dose escalation must be very slow since tofisopam slightly increase heart contractility which can give non-dangerous but scary transient heart palpitations for a limited subset of the population.
There are many interesting neuroprotectants/modulator e.g BPC-157, cerebrolysin, etc However the most promising treatment besides tofisopam, is a drug that is only available in japan: https://www.semanticscholar.org/paper/Effectiveness-of-Celep... It is likely that tinnitus is already a solved problem, but no one knows it yet besides a few retired scientists.
A complete pharmacological response would also look in synaptotrophics and in mitochondria targeted antioxidants, such as SkQ1
Any increase in GABA will counteract the excitatory transmission of Glutamate. That is all that matters.
But I know klonopin can eliminate my Tinnitus. So if you can explain how that works go right ahead.
> if you can explain how that works go right ahead Tinnitus is an excitatory overload localized in audition related neuron circuits. AKA too much glutamate (mGLURs, AMPA, NMDA, kainate). The brain is mostly a mixture of excitation (GLUT) and inhibition (GABA-A, B). By taking a classical benzo like klonopin you increase your GABA-A level which inhibit the overload of excitation (GLUT). That is why it works. You can also lower you glutamate levels independently of you GABA via an NMDA antagonist such as memantine. Those two mechanisms are the basic treatments to tinnitus. However there are more specific mechanisms (PDE, synaptotophics, calcium blockers, anti oxidants, bioenergetics) that can be complementary. Classical benzos and NMDA antagonists are not enough for some people with tinnitus.
Is this the same? I'm in Taiwan so googling to figure out what i could ask the pharmacist for to try.