>Ketamine, an N-methyl-D-aspartate receptor antagonist and putative antidepressant, may increase synaptic plasticity in prefrontal cortex through higher expression of BDNF. Furthermore, ketamine was shown to change resting-state functional connectivity (RSFC) of dorsomedial prefrontal cortex (dmPFC).

That is really fascinating! I wonder whether the lesions observed in chronic, heavy ketamine abuse are related to trophic effects.

A glance at search results sugget BNDF seems tighlty regulated, and linked to lesions in other rare conditions

(This makes me want to buy neuroscience books! Such an interesting field)