Apple isn't going to give up the substantial performance benefits of on-package unified memory in order to support DIMMs. Therefore I predict that we'll see a two-tier memory architecture with the OS making automated decisions based on memory pressure, as well as new APIs to allocate memory with a preference for capacity or performance.
The chassis design is new enough that it was designed with an eventual Apple Silicon Mac Pro in mind, so I expect to see minimal change to the exterior. It might shrink and have fewer slots (particularly since most users won't need a slotted GPU) though I think that's unlikely given that its height and width was defined by 5U rack dimensions.