One of my friends reminded me of CrossOver, which has eliminated that last small gap. And it is nice to finally be able to give back to the WINE community after using it for so long – I think my first use of WINE was Red Hat 9 in 2002.
The only one I can think of that isn't a total niche is SQL Server. Siemens NX dropped Mac support a while ago, but the Linux version is CLI-only. There are some more niche software (PaintShop Pro, A&B, Pro Motion NG) that suggest WINE for Linux users but I don't know how much that counts.