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"It was a fantastic game that spent a lot of time ruminating on topics like transhumanism, sex, and corporate power"I can't say anything about C2077 because I haven't played it, I can just repeat what Gibson said about it. And he didn't play it either, he was just judging the trailer.
What I can say is to note the three things you mentioned, "transhumanism, sex and corporate power" are also explored in other highly derivative and uninspired works of cyberpunk-influenced fiction, like Altered Carbon. Boy, was I disappointed by that show [1]! It's completely shallow, uninterested in exploring the philosophical ramifications of the technology it introduces, and instead goes for flashy visuals, endless action and explosive gore. I watched season 1 because I wanted to know whodunnit -- it was disappointing -- and season 2 was unbearable.
Whether you agree with me or not that Altered Carbon on Netflix was garbage, at least you must concede using those cyberpunk tropes you mentioned is not enough to determine quality or complexity of the plot and/or message. They are just tools in a toolbox, and can be used to build something interesting or something utterly uninspired, just another "gritty" cyberpunk copycat.
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[1] and from what my friends tell me, the book series is not fundamentally different. Only the details vary.