Absolutely. The challenge is having enough faith that it will take long enough to catch up to you.
Statistically speaking, it won't catch up to you and if it does, it will take so long you should have seen it coming from miles away and had time to prepare.
In my systems that use an in-memory/append-only technique, I try to keep only the pointers and basic indexes in memory. With modern PCIe flash storage, there is no good justification for keeping big fat blobs around in memory anymore.
