On the bright side, PySide has finally been adopted by Qt as its official bindings, and it has made PyQt largely redundant. I find it simplifies a lot Qt app development on desktop, and it has the potential to attract a lot of new developers to the platform.

While QtWidgets are stagnating and Qt Quick is arguably very "HUD"-centric and barebones for desktop development, there are nice portable UI toolkits such as KDE's Kirigami popping out that are very usable even without KDE.