For example, my custom domain is foo.mozmail.com. I enter my on the fly email address bar@foo.mozmail.com on attackers website. Voila. Now they know my custom domain name "foo" and can use it to send email to all possible on the fly addresses. e.g. 1@foo.mozmail.com 2@foo.mozmail.com so on and so forth.
Now my custom domain name as a whole is compromised but I can not change it anymore and lost all benefits of Firefox relay.