I'm able to get my first employee at around 2m30s. The trick is to blow balloons as fast as possible until you can afford helium, then alternate between blowing balloons and trading them for helium until you're producing balloons so fast that you can just keep clicking on helium, then click on helium until you have about 37,000 balloons / 800 helium, then stop clicking helium, wait to hit 45,000, sell all the balloons, and buy the employee.