There are definitely operations you cannot speed up in Python as much as in other languages, unless you implement it in one of those other languages and interface it in Python.
That much is obvious from Python providing a bunch of C-based primitives in stdlib (otherwise they'd just be written in pure Python).
In many cases, you can make use of the existing primitives to get huge improvements even with pure Python, but you are not beating optimized C++ code (which almost has direct access to CPU vector operations as well).
Python's advantage is in speed of development, not in speed of execution. And I say that as a firm believer that majority of the Python code in existence today could be much faster only if written with the understanding of Python's internal structures.
