There exist obese individuals that are not positive for those markers, and there exist non-obese individuals that are.
In a clinic, that might look like more proactively monitoring an obese patient for these indicators but not focusing as much on their obesity if those are doing well. Likewise, it might look like adding these tests to a 5 year physical (or whatever) for non-obese patients, since they appear to be especially suggestive of concern.