I'm very fond of two 4k monitors, one landscape and one portrait. The "main" landscape screen holds what Im focusing on, and the other screen gets documentation, references, unrelated chat, etc. I find this setup very productive.
I have sometimes run a 3rd screen, also landscape, above the primary; but its hard to give it much attention. Good for videos I'm not really watching or background stuff that might catch my attention when it blows up but doesn't demand any notice until then.