This is what led to the many request smuggling, its because the front-end proxy treats the request different from the backend proxy and parses the same HTTP text stream differently.
Since there is no framing there is no one valid way to say "this is where a request starts, and this is where a request ends and it is safe to continue parsing past the end of this request for the next request".
Servers are also allowed to close the connection at will. So let's say I pipeline Request 1, 2, and 3.
The server can respond to Request 1 with Connection: close, and now request 2 and 3 are lost.
That's the reason HTTP pipelining is not supported by browsers/most clients.
Curl removed it and there's a blog post about it: https://daniel.haxx.se/blog/2019/04/06/curl-says-bye-bye-to-...