Communication basically breaks down completely once you get to distances beyond just a few light years: consider a "small" interstellar kingdom within a 100 ly radius. The central world will always necessarily be 100 years (in terms of just time) away from the outer worlds. Something happens on the outer rim, the central world won't be able to know about it until 100 years after the fact.
So in essence, every world that's more than a few (e.g. less than 5 or so) light years away is practically isolated from the rest - both logistically and from a communications perspective. It's very hard to come up with any way of describing such a scattered collection of islands as one coherent civilisation.
Another issue is the colonisation process itself. It's virtually impossible to find a nearby 1:1 copy of a world that matches the point of origin of the civilisation. Therefore, terraforming (a lengthy and resource intensive process) or genetic modification would be required. The latter will occur naturally anyway, since some physical attributes of the target world simply cannot be changed without god-like powers (e.g. orbital parameters and gravitation). This means you'd end up with sub-species pretty quickly that won't share the exact same biology and probably have a very divergent culture as well due to being so isolated.
You'd have to come up with some really strong arguments as to how and why - given these circumstances - even "just" interstellar civilisations should be possible in the first place.