Just do whatever you're doing in docker natively in macos. Python, Nodejs, Ruby, Rust, Postgres, etc can all run as native macos processes.

The big advantage (aside from performance) is that you gain access to all the OS-native debugging capacities. You can just look at files, open multiple terminal sessions in the same folder, use Profiler, click the debug button without special configuration in your IDE, and so on. All without needing to think about VM images, docker containers, networking and all that rubbish.

The downside is you need to set up a second build environment (which might not match your deployment environment). Unless you're doing something truly special, setting up a macos-native build environment is usually pretty easy. Its normally just a few "brew install" / "npm" / "gem install" / "cargo build" etc commands away from working.