Yes, there are some definite losses in the move to a mouse based interface. I'm glad I had enough of a break from my last ASCII DF play, so my muscle memory isn't driving me insane. Some of the hotkeys are a little rough (requiring a big stretch across the keyboard or two hands on the kb but I'm using a mouse now..) and I hope they get another pass.
The real move is to get in the habit of forbidding your fancy stuff by default, and then using "closest material" and "keep building after placement" for all furniture.
