- vendor lock-in: anyone who has worked at a shop running Sun SPARC machines when they got purchased by Oracle can speak to the pain involved with negotiating software licenses or hardware support contracts with the Only Game In Town.

- the price/scarcity of mainframe talent: you're going to have to pry IBM z-series experts away from banks who are paying 50-100% over market rate, oftentimes in straight cash, to maintain systems that are propping up the United States economy in its entirety. Not to mention - my first job out of college >10 years ago had a mainframe, and I was incredulous that _anyone_ still had or needed one in the 21st century. Now I can appreciate the specific tradeoffs being made that caused the business to choose a mainframe, but attracting top-tier cost-effective junior dev talent out of college becomes several orders of magnitude more difficult once the word "mainframe" leaves your recruiters' lips.

- scalability: in the event that you ever decide to add features or functionality (or, say, increase your tweet character limit by an order of magnitude), you have now committed yourself to scaling your systems in units of mainframes costing millions per unit, as opposed to servers costing five figures per unit (not to mention, you probably need a dev environment that's airgapped from your prod environment, which means yet _another_ mainframe...)

- build vs. buy: using the same commodity x86_64/ARM hardware and Linux kernel that everyone else is using allows you to take advantage of all of the open-source datacenter software being built for that happy-path profile. The minute you stray from that path, the engineering-hour cost of everything you do has the potential to skyrocket, because you can't use anything off-the-shelf and need to recompile everything for z/Architecture. In fact, based on some cursory web searches, it doesn't appear that you can compile the Rust toolchain to even _run_ on z/OS as of today, so at minimum, OP would be committing to implementing that.

But at the end of the day, the constraining resource in every software organization I've encountered has been engineering hours, and by choosing a mainframe you're drastically limiting the potential number of engineering hours available to you in the employee market.