I hadn't considered that at all because they're so little used, but it would be an issue if they became so. I'm using Stylus for user styles nowadays which provides an option to allow you to target the CSS within an IFRAME using
html[stylus-iframe$="twitter.com"] h1 { display:none }
and I guess they could provide a similar sort of hack to select the Shadow DOM of an element to apply CSS e.g.
.comment:shadow .title { font-size: 1.1rem; }
Seems pretty likely to be be a performance hog to do that though.