The point is that you wouldn’t be removing it… ever. It would be your primary OS drive, sitting on the table forever with your Mac mini desktop. How would you wear out a port by leaving something plugged in?
I’m not talking about laptops. I specifically said that.
Regardless, USB-C has the springs in the cable, not the port (unlike Lightning), so the port should never fail with regular use anyways, but you may need to replace the cable at some point. You may need to clean the port out eventually, since gunk build up could make the connection feel looser with enough cycles, but then it should be fine again after cleaning. But again, I’m not talking about a laptop where you would be removing and reattaching the drive constantly, so this is completely off topic.
