While it is entirely possible the problem here is those execs, devs and bioinformaticians. There do seem to be many other common factors than the macs here.
Maybe they all need nonstandard software? God forbid, maybe they need administration permissions, but the org doesn’t want to give it to them, so they end up calling in every other day to get something unlocked (I know that’d be true for me).
Maybe it’s the problem solving skills of the IT team when it comes to mac, so people keep coming back with the same issues (good ones are Outlook/Teams being permanently broken, or VPN not connecting).
On the whole, I’d steer away from any explanation that would require all 500 mac users to be idiots.