All sorts of terrain issues that are minor for a car are dangerous for a bicycle, especially at higher speeds. Where I live, it's very hilly, so it's hard to go anywhere on a bike without hitting speeds of at least 25 mph at some point on the journey. Mechanical issues, unexpected objects in the road, or errors in piloting at that speed will result in an injury for sure.
[1] https://injuryfacts.nsc.org/home-and-community/safety-topics...
[2] https://www.nhtsa.gov/press-releases/2020-traffic-crash-data...