Largely yes. You don't need to survey every inch though since leaks aren't present in the middle of walls, but typically at complex areas (around windows, roof penetrations, can lights, outlets, rim joists, etc) so a little smoke quickly IDs those issue areas. Another way way to find leaks is to run the blower door tests on a day where there's a large temperature differential (ideally when it's very cold outside). You can use a thermal camera before the test and then after you depressurize the house for a 10 or 15 minutes - the leaky areas are perfectly obvious on the thermal since the cold outdoor air is washing over the walls near the leaks. Taking the before/during thermal videos on a walkthrough lets you compare the side-by-side later on and ID which spots need attention.
