If I only need to read some text or code, the line length does not matter, because the sound from the screen reader is linear by nature. There is something to be said about natural breaks on statements and the like, but we assume that we are talking about expressions which just happen to be long.

If I need to edit though, I need to navigate to the section in question. My options are to use word by word navigation either from the line start or word by word from the line end (I have short keys for those). If the line is too long, word by word might take quite the number of keystrokes to reach the target position. ctrl+f might be faster. Some vim magic might be useful for such cases, but it would be an overkill.

Separately, there could be some attention fatigue if I need to here only the end of the line, but it is long and my mind wanders while waiting for the interesting bits. This is a corner case though.