Yes, market regulators can issue halt orders to stop all trade regarding affected stocks, but that still has the potential to cause widespread and immense loss of value.
People going long for no reason but "420.69 $GME" are funny to laugh at, and if they buy the right options they can make a lot of money, but there is no potential of cascade events.
Therefore, it makes sense to keep a close watch and a tight leash on shortsellers.