https://www.biorxiv.org/content/10.1101/2021.12.28.474326v1....
> "The intranasal dose of TriSb92 that should be administered to susceptible persons prior to events involving a risk for SARS-CoV-2 exposure remains to be established but is likely to be substantially lower than extrapolation of our current data on mice that were challenged by inoculation of the rather massive amount of 2x105 PFU of SARS-CoV-2 into their respiratory tract."
Side effects might be an issue but that should show up in well-designed clinical trials. It sounds like something that people working in infectious clinical settings might want to use, maybe immunocompromised people who have to go out in public, but otherwise, for general use seems iffy in terms of efficacy.
The former is a measure of how effective something is, in absolute terms.
OP might mean that because the protection isn't complete or permanent, it might not make sense for an otherwise healthy person to use it unless they expect to be in close quarters with a lot of possibly-sick people. Too early to say, ofc.
[1] common cold: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880062/#:~:tex.... [2] covid: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493111/
It's one of the biggest reasons I don't want to return to working in an office any time soon.
I'm not blindly trusting of corporations, but the manufacturer's claims are likely to be a better guide than anecdotes, at least in a country with reasonable regulation of medicines and medical claims.
not really.
they're both equally poor.
even if the manufacturer has clinical trials, they often need to be treated with skepticism.
(i.e. All of it is equally bad/biased "data")
The pandemic is real, and we need to trust the experts here
- https://www.pandemblock.com/products
- https://www.nature.com/articles/s41467-023-37290-6
Q: how would this be to take, if it's ever human certified? Are there similar nasal immunity products, using similar molecular mechanisms?
Nasodine Nasal Spray is based on povidone-iodine, the same active ingredient found in Betadine throat gargle, and has been in development for almost a decade as a treatment for the common cold. Laboratory experiments showed a 15-second exposure to the nasal spray reduced infectivity of SARS-CoV-2 by 99.97 per cent, while a 60-second exposure completely eliminated viral infectivity.
A subsequent pilot study of six COVID-19 patients, who were shedding the virus from the nose, looked at whether the laboratory results translated to people. https://www.uwa.edu.au/news/Article/2022/February/Study-find...
> In laboratory animal studies, a molecule known as TriSb92...
Obviously not, because the vast majority were fully up to date with all the usual established jabs.
While it's been officially launched, hospitals simply aren't procuring them because there is approximately zero demand. As a result, you can't actually get them.
I had the vaccine but certainly wouldn’t blame anyone for being hesitant to take a new style of delivery and action (mRNA) that until Covid never once made it past phase three trials. But hey, yea, if we boil it down to “dummies afraid of needles” then we’re all set!
Anyway, so no I don’t care about injections, I care that the same people who obviously lied to us 6 times, are the people who tell us “This time, we’re right, we know what we’re doing.”
The show Chernobyl is excellent in demonstrating how each type of personality deals with news in a regime where everything is false, some of them not even having recognized that the communist regime’s output were systematic lies.
So what happened to Facebook censoring doctors because they said the virus would behave in waves, and at that time, the theory of waves was a conspiracy, so we shouldn’t have known about it?
It's pretty much common sense, most bacteria and viruses for respiratory infections live in the upper respiratory tract and multiply there. Kill them at the source and your infection tends to resolve much faster...
As a nasal spray? The wikipedia article describes it as being primarily used on skin. Is it safe to spray that into your nose?