- Activities staying inside state lines
should be subject to federal regulation so that children don’t die due to breathing in coal dust at work, or so that people don’t get poisoned by lead in the air and water;
- Activities staying inside state lines should not be subject to federal regulation so that people don’t get sent to prison in droves for what is essentially a medical problem.
Seems to me like federal regulation is fairly value-neutral, as in usable in equal measure for both good and evil. The tricky part is deciding which is which, of course.