Desomorphine seems kind of bad, even without the other nasty effects when it is homemade by people who can't afford the real thing (i.e. Krokodil).
https://en.wikipedia.org/wiki/Desomorphine
> While desomorphine was found to be faster acting and more effective than morphine for the rapid relief of severe pain, its shorter duration of action and the relatively more severe respiratory depression produced at equianalgesic doses, as well as a high incidence of other side effects such as hypotension and urinary retention, were felt to outweigh any potential advantages.[15][16]
From [15] we have: short duration which is independent of dose, tolerance, persistent decrease in respiratory rate, <when used to treat severe chronic pain> less sleep compared to morphine, possible greater withdrawal symptoms than morphine.
For medical uses [15] cites some good uses where it is preferable to morphine, but this is a drug that's even more worthy of regulation than morphine itself.
