It makes it very easy for me (as someone who comes from a world of physical datacentres) to reason about what an AZ is getting me, and also to understand the benefits of using AWS (not having to think about the details of power routing, blade switch vs top-of-rack vs core switch, storage cabling, blah blah blah).
If I have to think too hard and do too much work about how I lay applications out, I might as well just rent in a colo.