Please bear in mind that mathematical notation is a language, and that mathematical formulas are perfectly valid plain prose in that language.
I imagine that some screen readers will fail gracelessly when faced with Chinese script or Hindu as well. Especially if they're not unicode compliant.
But once you hit that threshold you are simply in a battle of dueling accessibility concerns. Not everyone is sighted, but neither does everyone rely on English as a primary language.
Nor should they as the English language was not designed to convey all concepts accurately. It excels mostly in conveying concepts germane to anglophone cultures. And three guesses what concepts are not popularly relevant to your standard anglophone? That's right.. calculus and theoretical physics.
That's not to bash on English as a language. It really is a flexible beast with a far reaching vocabulary. But there literally exists no language that is ideal for encapsulating every single idea under the sun. One must have a way to support many of the most diverse ones at the same time. And modern mathematical notation belongs on that short list along with English.