1. fsync. You cannot "divide" it between containers. Whoever does it, stalls I/O for everyone else.
2. Context switches. Unless you do a lot of configurations outside of container runtime, you cannot ensure exclusive access to the number of CPU cores you need.
3. Networking has the same problem. You would either have to dedicate a whole NIC or SRI-OV-style virtual NIC to your database server. Otherwise just the amount of chatter that goes on through the control plane of something like Kubernetes will be a noticeable disadvantage. Again, containers don't help here, they only get in the way as to get that kind of exclusive network access you need more configuration on the host, and, possible an CNI to deal with it.
4. kubelet is not optimized to get out of your way. It needs a lot of resources and may spike, hindering or outright stalling database process.
5. Kubernetes sucks at managing memory-intensive processes. It doesn't work (well or at all) with swap (which, again, cannot be properly divided between containers). It doesn't integrate well with OOM killer (it cannot replace it, so any configurations you make inside Kubernetes are kind of irrelevant, because system's OOM killer will do how it pleases, ignoring Kubernetes).
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Bottom line... Kubernetes is lame from infrastructure perspective. It's written for Web developers. To make things appear simpler for them, while sacrificing a lot of resources and hiding a lot of actual complexity... which is impossible to hide, and which, in an even of failure will come to bite you. You don't want that kind of program near your database.