If you're willing to carry around a second monitor and an eGPU, what's the point of even having a laptop as part of that setup?
For example, consider a small form factor desktop in a case like this one in the DAN C4-SFX: https://www.youtube.com/watch?v=XiCwDRzLHDk
What percentage of extra weight/space is this compared to carrying a laptop, eGPU, and second monitor? Could you not just carry two larger sized portable displays and the ITX desktop system and have the same outcome (but with better modularity and price/performance value)?
In my opinion, most people who want portable gaming are fine with buying a typical gaming laptop which they'll probably get many years of above-console quality gaming out of. That laptop-wattage 4080 you mentioned is more than good enough for playing literally any game. The people who feel like "as long as it fits in a duffel bag it's portable" and want the most performance possible should probably skip the eGPU and just travel with an ITX build desktop PC.
In other words, an eGPU fits in a weird middle zone between those two solutions that doesn't make a lot of sense. It's saving you a very slight amount of kit over just carrying a desktop around with you, and it's the most costly solution.