No idea about Paint.Net but there is not a single thing i could name that I am missing with Gimp.
The only downside of Inkscape is that it doesn't properly open and save the most recent Adobe formats other than that I also have no idea why I would need anything more than what Inkscape offers.
Sure the Adobe tools have a lot to explore, a lot of buttons and options hidden in millions of submenus.
But a good portion of computer users have only a limited need for tools like this, no interest in that constant learning curve after major updates and no use for all those advanced features.
Imagine I learned using these tools 20 years ago, and while they heavily improved they still work exactly the same. Every time I meet Photoshop it 180d their design and button placements...
My point is you do not need to feature match Adobe to compete, making it more accessible alone could be a selling point.