Not by itself! But together with other library boxy you can: https://github.com/treeform/boxy

You should use pixie to load textures, create text, rasterize vector graphic etc... and send them to boxy to be drawn every frame.

Yes Pixie is CPU only, and just like you can't use Cairo or Skea for real time games you can't use Pixie, but boxy you totally can.

I use pixie for my game framework. It's used to load textures, layout fonts, and render font atlases. It can be used for generative art but https://github.com/EriKWDev/nanim or sdl2 using renderer's makes more sense as they are gpu accelerated.