Using a case-sensitive filter (default for Django) in a DB with case-sensitive collation (default in Postgres)? Django will helpfully cast the tuple and your query to UPPER to match it for you, and the former wrecks indexing.
Checking if a string ends with something else? Goodbye, index.
I _think_ the latter can be worked around in PG with a GIN index, but I’m not positive (I work with MySQL much more). And in any case, you’d have to know to create that, and I imagine most devs won’t.
Fixing seemingly tiny things like that have a massive impact on large table query speed.